Liver and blood disorders are the common pathogenesis of gynecological diseases. Professor GUO Zhiqiang believes that liver stagnation in women is different from the actual symptoms of liver Qi in men, which are mostly caused by deficiency of Yin and blood, and lack of blood to soften the liver, resulting in loss of liver circulation. Therapy is therefore "better to soften the liver than to clear it". Professor GUO Zhiqiang‘s unique approach of adding and subtracting with the evidence based on the formula , which is representative of nourishing blood and softening liver, is very effective in treating gynecological diseases caused by imbalance of liver and blood, also fully reflecting the characteristic of "treating different diseases with the same evidence" in Chinese medicine. This article contains four cases of professor GUO Zhiqiang using Yiguanjian to treat gynecological diseases from the perspective of liver and blood: ①Nourishing Yin and blood to soften liver, supplemented by tonifying kidney and strengthening spleen to treat hypochondriac amenorrhea caused by kidney deficiency and liver depression.② Nourishing Yin and blood, inducing fire to return to the vital energy to treat menstrual erosion due to deficiency of Yang. ③ Nourishing Yin and blood, supplemented by inducing heat to move downward to treat deficiency of heat due to epistaxis during menstruation. ④ Nourishing Yin and blood, softening tendons and opening the ligaments to treat postpartum body pain caused by deficiency of Yin and blood and loss of nourishment of tendons and veins. This article also provides an in-depth analysis of the clinical application of professor Guo‘s academic thought that "for women, softening the liver is better than detoxifying it" in gynaecological diseases.