Oligospermia is one of the common causes of male infertility, and there are many factors leading to oligospermia. This article analyzes the relationship between Qi, blood, god and essence based on the theory of Qi and blood, and analyzes the basic pathomechanisms of oligospermia and oligozoospermia. Combined with the clinical experience of famous Chinese doctors and Doctor. Zhang Chunhe, it analyzes the mechanism of Ren Shen, Huang Qi, Bai Zhu, Dang Gui,San Leng, E Zhu,Tao Ren and Niu Xi in the treatment of oligozoospermia and weak spermatogenesis, and points out that benefiting the Qi and nourishing the blood, nourishing the kidneys to produce essence, and promoting the movement of the Qi and activating the blood may be a one of the major method of treating oligozoospermia.