Objective To investigate the efficacy of Wuzi-Yanzong-Wan(WZYZW) combined with moxibustion (hereinafter referred to as "combined group") on treatment for asthenozoospermia of kidney-yang deficiency type. Methods A parallel controlled randomized study was conducted to collect 70 asthenozoospermia patients who met the inclusion criteria, which included 29 and 33 cases in the combined and control groups were statistically analyzed. The control group was given WZYZW, while the combined group was treated with moxibustion combinedwith WZYZW. With a three months treatment, the two groups adopted semen routine analysis(sperm motility and sperm viability rate) and the TCM clinical syndrome scores, and the clinical efficacy were evaluated. Results The proportion of sperm motility(Grade A and A+B) and sperm viability rate in the combined group were higher than those before treatment(P<0.05), and were better than those in the control group(P<0.05). The total score and sub-item scores(apathy of sexual desire, impotent ejaculation, soreness and weakness of waist and knees, cold shape and cold limbs, and frequent urination at night) of TCM syndrome scalein in the combined group were lower than those before treatment(P<0.05), and the total score and sub-item scores(soreness and weakness of waist and knees, cold shape and cold limbs) in the combined group were lower than those in the control group (P<0.05). The total effective rate was 82.76% in the combined group and 60.61% in the control group, and the difference was significant (P<0.05). Conclusion The Moxibustion combined with WZYZW on treatment for asthenozoospermia is significantly better than that of WZYZW, which can effectively improve sperm motility and sperm viability rate, improve the clinical symptoms of TCM, and has efficacy.