Objective To observe the clinical efficacy of compound Sanhuang Decoction in the treatment of fire poison epididymitis with traditional Chinese medicine osmosis therapy. Methods A total of 52 patients with epididymitis were randomly divided into two groups, the control group was given intravenous drip ceftriaxone plus magnesium sulfate gauze scrotum local wet compress, and the experimental group was given intravenous ceftriaxone plus compound Sanhuang Decoction to partially Chinese medicine osmosis therapy scrotum. The efficacy was judged after 7 days of treatment. Results The total effective rate of the experimental group was 92.00%, which was higher than that of the control group(P<0.05). After 7 days of treatment, the total number of white blood cells, neutrophil ratio and C-reactive protein in the blood routine of the two groups decreased in both groups, and the total number of white blood cells in the experimental group significantly decreased compared with the control group (P<0.05), and the scrotal B-ultrasound of the experimental group showed that the swelling of the affected epididymis subsided significantly. Conclusion Compound Sanhuang Decoction traditional Chinese medicine osmosis therapy has a significant effect in the treatment of fire poison epididymitis, which can quickly improve symptoms, shorten the course of treatment, improve the effective rate, and have no adverse effect.