Objective To conduct data mining analysis on the traditional Chinese medicine preparations with the effect of "tonifying the kidney", to provide a reference for the further standardization of traditional Chinese medicine preparations, to reveal their medication rules and to discover potential new prescriptions. Methods Taking the 2020 edition of "Chinese Pharmacopoeia" (Part I) as the data source, the relevant traditional Chinese medicine preparations with the effect of invigorating the kidney were screened, and the information were collected. such as prescription, dosage form, nature, flavor, meridian, function and indication, usage and dosage, precautions, etc. Microsoft Excel 2019 established a database for frequency analysis; used SPSS modeler 18 to perform association rule analysis and complex network analysis on drugs with a frequency of ≥20 times; used SPSS Statistics 26.0 statistical software to perform systematic cluster analysis and analysis of traditional Chinese medicine with a frequency of ≥20 times for. factor analysis. Results A total of 192 traditional Chinese medicine preparations were included, involving 308 traditional Chinese medicines. It was found that there are some deficiencies such as unclear contraindications and unclear courses of treatment. The most common dosage forms are pills, which mainly treat diseases related to the genitourinary system and sex hormones. Insufficiency of liver and kidney is the most common syndrome type, and tonifying kidney Qi is the most commonly used treatment. Gan and Wen are more common, the frequency of liver meridian is the highest, and the tonic medicine is the most widely used; Rehmannia glutinosa-dogwood, Rehmannia glutinosa-yam+Poria are the drug combinations with the highest confidence or support. Nine common factors were extracted, and 5 were found. A new clustering method was used to construct a core drug network. Conclusion The study found the deficiencies in the basic specifications of its preparations, and explored the commonly used drug pairs, core drug combinations and clustered new prescriptions, which provided a reference for further standardizing the description of Chinese medicine formulations, and provided information for clinical treatment of traditional Chinese medicine and new drug research and development. Literature basis.