In recent years， semen non-liquefaction symptom is one of the main common pathological causes leading to male infertility. We analyzed the basic pathogenesis of semen non-liquefaction based on the theoretical system of "Yang transforms Qi and Yin forms" in the "Huang Di Nei Jing"， and believed that the main pathogenesis of semen non-liquefaction lies in the balance of Yin and Yang in the kidney， deficiency of Yuan Yang， and insufficient Qi Hua function. So we should accurately grasp the basic treatment principles of reconcile the balance of yin and yang， warming the yang to produce gas， and make good use of the method of seeking yang in yin， and nourish yin when it is warm and yang， so that yang can be helped by yin and biochemical infinity.