Human papilloma virus(HPV) is one of the most common sexually transmitted viruses. Many research has been done on the natural history and consequences of HPV infection in women, but relatively there is a little known about the epidemiology of associated HPV infection in men. Male HPV infection is closely related to the development of genital warts and malignant tumors such as penile cancer, perianal cancer, and oropharyngeal cancer, which seriously endangerment men‘s physical and mental health. With the change of sexual concept and diversification of sexual orientation, the infection rate of HPV in men is increasing year by year. This article reviews the literature from the aspects of modern medical research on HPV infection, the understanding of male HPV infection in traditional Chinese medicine, prevention before disease, and prevention of pre-existing disease, so as to provide reference for the prevention and control of male HPV infection with traditional Chinese medicine.