Objective To comprehensively assess the effect of traditional Chinese medicine in the treatment of male climacteric syndrome by means of meta-analysis. Methods PubMed, cochrane Library, web of Science, CBM, CNKI, VIP, wanfang and other databases were searched by computer, and relevant literatures were retrieved manually. A randomized controlled trial(RCTS) on the treatment of male menopause syndrome with traditional Chinese medicine was screened from the self-built database until April 2023, and literatures were screened and analyzed by 2 researchers strictly in accordance with the established criteria. Data were extracted from eligible trials after quality assessment using the cochrane bias risk assessment tool. RevMan5.4 software was used for analysis. Results A total of 16 qualified literatures were included,including 1 220 patients. Meta-analysis resultsshowed that the physical fitness/cardiovascular score(MD= -0.87, 95%CI[-1.55, -0.20], P=0.01) and psychologic score (MD=-0.47, 95%CI[-0.88, -0.05], P=0.03) were improved in the experimental group, and the efficacy was better than that in the control group. However, sexual function score, serum T, SHGB, LH, FSH, E2 and there was no statistical significance in clinical efficacy compared with the control group. Conclusion The overall efficacy of traditional Chinese medicine in the treatment of male climacteric syndrome is similar to that of testosterone replacement therapy, and superior to that of testosterone replacement therapy in physical fitness/cardiovascular and psychopsychological scores.