Traditional Chinese medicine acupuncture and moxibustion has significant analgesic effect without obvious adverse reactions, which is internationally recognized and is often used as an auxiliary treatment for pain. Neuromyelitis optica spectrum disorders is an immune-mediated autoimmune disease in which the optic nerve and spinal cord are involved simultaneously or successively. It is more common in Asian population and has the characteristics of high recurrence rate, long course of disease and high disability rate, which seriously affects the quality of life. Pain is particularly common in patients with neuromyelitis spectrum diseases, up to more than half of neuromyelitis of patients with neuromyelitis spectrum diseases can have pain, and the drug treatment is not good. This article aims to summarize the clinical effect of acupuncture on neuropathic pain associated with optic neuromyelitis spectrum disease.