“乌附抑酸汤”治疗胃食管反流病(水寒土湿木郁型)的中医症候疗效观察研究
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昆明市中医医院

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Observation and Study on the Therapeutic Effect of Traditional Chinese Medicine on Gastroesophageal Reflux Disease (Water Cold Soil Dampness and Wood Depression Type) with "Wu Fu Yi sour Tang"
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Kunming Traditional Chinese Medicine Hospital

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    摘要:

    目的:观察自主研制的“乌附抑酸汤”治疗胃食管反流病(水寒土湿木郁型)患者的临床症候疗效。方法:选取72例GERD患者,按随机对照试验原则分为治疗组和对照组,其中治疗组36例,服用乌附抑酸汤(颗粒剂型),每日3次;对照组36例,服用香砂六君子汤(颗粒剂型),每日3次,治疗4周。疗程结束后比较治疗前后两组患者的中医症候积分及症状评分变化情况,并评价2组治疗的安全性。治疗结束4周后随访,比较2组患者的复发率。结果:(1)治疗后,2组患者的中医证候评分均较治疗前明显改善(P<0.05),且治疗组在改善中医证候评分方面均明显优于对照组,差异均有统计学意义(P<0.05)。(2)治疗后,2组患者的症状评分(RDQ及GERDQ量表积分)均较治疗前明显改善(P<0.05),且治疗组在改善RDQ及GERDQ量表积分方面明显优于对照组,差异有统计学意义(P<0.05)。(3)治疗后,治疗组焦虑自评SAS量表积分、抑郁自评SAS量表积分均较治疗前明显改善(P<0.05),对照组SAS、SDS量表积分较治疗前无统计学意义(P﹥0.05);(4)治疗组总有效率为100.00%(36/36),对照组总有效率为81%(29/36),治疗组疗效优于对照组,差异有统计学意义(P<0.05)。(4)治疗组复发率为5.56%(2/36),对照组复发率为22.22%(8/36),治疗组复发率明显低于对照组,差异有统计学意义(P<0.05)。(5)治疗期间,2组患者均无明显不良反应情况发生,差异无统计学意义(P>0.05)。两组患者治疗前、后(心电图、血常规、肝、肾功能)等安全性指标比较均无统计学差异(P﹥0.05)。结论:“乌附抑酸汤”能明显改善胃食管反流病(水寒土湿木郁型)患者的临床症状,且疗效显著,具有较好的临床推广应用价值。

    Abstract:

    Objective: To observe the clinical efficacy of the self-developed "Wu Fu Yi Sour Tang" in treating patients with gastroesophageal reflux disease (water cold soil dampness wood depression type). Method: 72 GERD patients were selected and divided into a treatment group and a control group according to the principle of randomized controlled trials. Among them, the treatment group consisted of 36 patients who took Wufu Yisuan Tang (granule type) three times a day; 36 cases in the control group were treated with Xiangsha Liujunzi Tang (granule type) three times a day for 4 weeks. After the end of the treatment course, compare the changes in traditional Chinese medicine symptom scores and symptom scores between the two groups of patients before and after treatment, and evaluate the safety of the two groups of treatment. Follow up after 4 weeks of treatment to compare the recurrence rates between the two groups of patients. Result: (1) After treatment, the TCM syndrome scores of both groups of patients were significantly improved compared to before treatment (P<0.05), and the treatment group was significantly better than the control group in improving TCM syndrome scores, with statistical significance (P<0.05). (2) After treatment, the symptom scores (RDQ and GERDQ score) of both groups of patients were significantly improved compared to before treatment (P<0.05), and the treatment group was significantly better than the control group in improving RDQ and GERDQ score, with statistical significance (P<0.05). (3) After treatment, the scores of the Self Rating Anxiety Scale (SAS) and the Self Rating Depression Scale (SDS) in the treatment group were significantly improved compared to before treatment (P<0.05), while the SAS and SDS scores in the control group were not statistically significant compared to before treatment (P>0.05); (4) The total effective rate of the treatment group was 100.00% (36/36), while the total effective rate of the control group was 81% (29/36). The therapeutic effect of the treatment group was better than that of the control group, and the difference was statistically significant (P<0.05). (4) The recurrence rate of the treatment group was 5.56% (2/36), while that of the control group was 22.22% (8/36). The recurrence rate of the treatment group was significantly lower than that of the control group, and the difference was statistically significant (P<0.05). (5) During the treatment period, there were no significant adverse reactions in both groups of patients, and the difference was not statistically significant (P>0.05). There was no statistically significant difference in safety indicators such as electrocardiogram, blood routine, liver and kidney function between the two groups of patients before and after treatment (P>0.05). Conclusion: "Wu Fu Yi Sour Tang" can significantly improve the clinical symptoms of patients with gastroesophageal reflux disease (water cold soil dampness wood depression type), and the therapeutic effect is significant, with good clinical promotion and application value.

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  • 收稿日期:2024-02-07
  • 最后修改日期:2024-03-26
  • 录用日期:2024-04-30
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