Objective To investigate the target and potential mechanism of action of Artemisia Caruifolia in the treatment of lupus nephritis based on network pharmacology. Methods The chemical active ingredients and targets contained in A. caruifolia were retrieved from TCMSP database, and the names were standardized in Uniprot database. We then searched LN-related genes using OMIM and GeneCards databases, drew a Wayne diagram using R software and screened out the common targets of A. caruifolia for the treatment of LN, constructed a protein-protein interactions(PPI) network using the String database, and constructed a drug-disease-target(DDT) network using the Cytoscape 3.8.0 software, and then screened out core genes, and then performed GO functional enrichment and KTD on common target genes. The core genes were screened out and analyzed for GO function enrichment and KEGG pathway enrichment. Results 22 active ingredients were obtained from A. caruifolia, 42 targets were obtained by removing duplicates, 842 targets were related to LN, and 10 drug-disease co-targets were screened out by using the Wayne diagrams, and the GO function enrichment analysis showed that the biological processes and functions of A. caruifolia in treating LN were mainly focused on the bacterial response, the membrane microregion, cytokine receptor binding, signaling receptor modulating activity et al. KEGG pathway enrichment analysis showed that the treatment of LN by A. caruifolia was mainly related to AGE-RAGE signaling pathway, fluid shear stress, TNF signaling pathway, lipids and atherosclerosis, PI3K/AKT signaling pathway and IL-17 signaling pathway. Conclusion By analyzing the main active ingredients of the drug, constructing PPI network and Artemisia-active ingredient-target-disease network diagram and performing GO function enrichment and KEGG pathway enrichment analysis, it reveals that the treatment of LN by A. caruifolia has the characteristics of multi-components, multi-targets and multi-pathways of action, and it provides ideas and methods for the mechanism of A. caruifolia‘s clinical application in the treatment of LN.