Cimicifuga genus has a global distribution of about 18 species, mainly distributed in the northern hemisphere temperate zone. There are eight species distributed in most provinces of China. Some plants of Cimicifuga genus has a long history of medicinal use in domestic and at abroad. In China, it is commonly used in flu-like illness, sore throat, and measles, as well as pain relief, while in Europe and the North America, it was mainly used to alleviate menopausal syndromes caused by women's perimenopausal hormonal imbalance, such as hot flash and osteoporosis. In this paper, we review the researches on materia medica of Cimicifuga spp. and its medicinal researches, with a hope to provide reference for the subsequent clinical medicinal research.