白背叶楤木乙酸乙酯部位化学成分研究
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1.云南中医药大学中药学院;2.云南中医药大学第一附属医院

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国家自然科学基金(82260832,81860760);云南省中医联合专项(202101AZ070001-159,202001AZ070001-044);云南省重大科技专项(202002AA100007)


Chemical constituents of ethyl acetate fraction of Aralia chinensis var. nuda
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1.College of Traditional Chinese Medicine,Yunnan University of Chinese Medicine;2.The First Affiliated Hospital of Yunnan University of Chinese Medicine;3.College of Traditional Chinese Medicine, Yunnan University of Chinese Medicine

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    摘要:

    目的 研究白背叶楤木Aralia chinensis Linn. var. nuda Nakai芽苞的乙酸乙酯萃取部位的化学成分。方法 白背叶楤木芽苞70%乙醇提取物的乙酸乙酯萃取部位经硅胶、ODS、Sephadex LH-20以及半制备HPLC等分离纯化后,根据理化性质及波谱数据鉴定所得化合物的结构。结果 从白背叶楤木乙醇提取物的乙酸乙酯萃取部位分离得到12个化合物,分别鉴定为邻苯二甲酸(2,5-二甲基己基)二酯(1)、(9E)-8,11,12-trihydroxyoctadecenoic acid methyl ester(2)、methyl (9S,10R,11E,13R)-9,10,13-trihydroxyoctadec-11-enoate(3)、capillasterolide(4)、二十六烷(5)、 (-)-loliolide(6)、methyl hematinate(7)、对羟基苯乙胺(8)、(S)-methyl 2-acetamido-3-phenylpropanoate(9)、异香草酸(10)、vanillic acid(11)、p-hydroxybenzoic acid(12)。结论,化合物1~10为首次从该属植物中分离得到,化合物1~11为首次从白背叶楤木中分离得到。

    Abstract:

    Aim to study the chemical constituents of ethyl acetate extraction of Aralia chinensis Linn. var. nuda Nakai. Method The ethyl acetate part of 70% ethanol extract of Aralia chinensis Linn. var. nuda Nakai was purified by silica gel, ODS, Sephadex LH-20 and semi-preparative HPLC, and the structure of the compound was identified by the physicochemical properties and spectral data. Results Twelve compounds were isolated and identified as phthalic acid, bis-(2, 5-dimethylhexyl) ester (1), (9E)-8,11,12-trihydroxyoctadecenoic acid methyl ester (2), methyl (9S,10R,11E,13R)-9,10,13-trihydroxyoctadec-11-enoate (3), capillasterolide (4), hexacosane (5), (-)-loliolide (6), methyl hematinate (7), tyraminel (8), (S)-Methyl 2-acetamido-3-phenylpropanoate (9), 3-hydroxy-4-methoxybenzoic acid (10), vanillic acid (11), p-hydroxybenzoic acid (12). Conclusion Compounds 1-10 are isolated from this genus Aralia for the first time, and compounds 1-11 were first isolated from the plant.

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  • 收稿日期:2024-04-07
  • 最后修改日期:2024-05-31
  • 录用日期:2024-06-06
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