Alzheimer‘s disease is a progressive degenerative disease of the central nervous system. The effectiveness of acupuncture in the treatment of AD has been confirmed by many studies, but the related mechanism remains to be further clarified. "microbiota-gut-brain axis" is closely related to the pathogenesis of AD, and has become a new target for the prevention and treatment of AD in recent years. Traditional Chinese medicine believes that the brain and intestine meridians are interrelated in circulation and affect each other in physiology and pathology. Acupuncture has the function of overall regulation and two-way benign regulation, and can be used as a microecological regulator to regulate the "microbiota-gut-brain axis" in a benign way. However, the intestinal mechanism of acupuncture in treating AD needs to be further clarified. This study analyzes the relationship between "microbiota-gut-brain" and AD, and explore the mechanism of acupuncture treating AD through "microbiota-gut-brain", in order to provide new ideas for the treatment of AD.