To introduce Professor Li Yingdong‘s clinical experience of using wumei pill to treat coronary heart disease through theoretical discussion and case analysis. The article in "Treatise on Febrile Diseases" was discussed theoretically, the composition, efficacy and indications of wumei pill were analyzed, and clinical cases were listed for discussion. As a representative prescription for jueyin disease, wumei Pill can not only warm yang and dispel cold, but also dispel evil of jueyin meridian, and the whole prescription can be used for the treatment of coronary heart disease. Professor Li Yingdong believes that the core pathogenesis of coronary heart disease is "Yang mild Yin string" and its occurrence is closely related to jueyin disease, As a representative prescription for jueyin disease, wumei pill can be used in the treatment of coronary heart disease.