The theory of "the liver is responsible for regulating and releasing Qi" has a long history, which refers to the liver's ability to promote its own ascending characteristics and achieve the functions of unblocking, relaxing, and regulating. This article focuses on the theoretical basis of "the liver is responsible for regulating and releasing Qi". Through tracing the connotation of this theory, exploring its physiological and pathological states, and summarizing the achievements of modern medical research, the relationship between this theory and pediatric nasal diseases is elaborated. The etiology, pathogenesis, treatment differentiation, and medication selection of pediatric allergic rhinitis, sinusitis, nasal congestion, and nosebleeds under the guidance of this theory are discussed. It is suggested that clinical treatment of pediatric nasal diseases should be paid attention to restoring the physiological function of the liver in regulating and releasing Qi. Finally, an experimental case is attached for reference.