Chronic cough is a common clinical condition in paediatrics, which is prolonged and difficult to heal and easy to recur, cough as a sound and phlegm, although the five organs and six bowels are cough. But cough, especially chronic cough, because of its complex etiology and pathogenesis increases the difficulty of clinical diagnosis and treatment, especially the chronic cough of paediatrics with deficiency of spleen and Yin, the generations of physicians and modern textbooks mentioned less, shallow, or although there is a thesis, but it lacks of the completeness of the system. Therefore, the author would like to analyse the etiology and pathogenesis of paediatric chronic cough based on spleen-Yin deficiency, and at the same time, elaborate on the clinical manifestations of chronic cough with spleen-Yin deficiency as the core of diagnosis and treatment principles, as well as list the relevant representative prescriptions for the diagnosis and treatment of chronic cough, which can achieve significant therapeutic effects, with a view to discussing the clinical value and significance of its application in practice. It may provide a certain basis for the treatment of paediatric chronic cough based on spleen-Yin deficiency in clinical practice, and also the clinical management of chronic cough based on spleen-yin deficiency. The clinical value and significance of this study will be discussed from the aspect of practical application.