Abstract:ABSTRACT:Objective: To provide research ideas for later researchers to explore the best combination therapy for post-stroke cognitive impairment and related basic research. Methods: The Chinese and English literatures of Pubmed, Web of science, CNKI,Wanfang DATA, Vip Chinese Periodic Service Platform in recent 5 years were searched, and the clinical efficacy observation and basic mechanism research in this field were sorted out. Results: At present, most of the researches on acupuncture combined with modern rehabilitation in the treatment of cognitive impairment after stroke are clinical research. the main mechanism research focuses on the combination of acupuncture and moxibustion with drugs, cognitive rehabilitation training, transcranial direct current stimulation and transcranial magnetic stimulation can significantly improve the serum brain-derived neurotrophic factor, improve synaptic plasticity and balance oxidative stress in patients with post-stroke cognitive impairment. Conclusion: at present, there is no definite evidence-based treatment for cognitive impairment after stroke. Studies have shown that the clinical effect of combined therapy is better than that of single acupuncture or rehabilitation therapy, and the best combination therapy still needs to be further explored. The systematic mechanism research still needs to be improved.