Objective To explore the clinical application rule of Xiehuang San in pediatrics through sorting out modern medical cases and data mining. Methods Searching Xiehuang San as a keyword in CNKI, Wanfang and VIP databases. Selecting complete clinical dates and definite curative medical records to build a database. Using SPSS 23.0 to analysis the date. Results There are 89 valid medical cases, 31 types of Western medicine diseases, 41 types of TCM symptoms, 11 types of TCM signs and 14 types of TCM pathogenesis, 118 prescriptions, 205 kinds of drugs, and the total frequency of medication was 1 400 times. Except Xiehuang San, Peony bark, Cicada slough, Coptis chinensis,Rehmannia glutinosa and Radix Paeoniae Rubra were often added ,which frequency more than 20 times; statistics were made on the frequency of each drug in Xiehuang San, the results showed that the most frequent were Huoxiang 10 g, Fangfeng 10 g, Gardenia 10 g, Gypsum 15 g and Glycyrhiza 5 g. The largest was gypsum with an average of 36.04%, the Fangfeng(18.71%) Huoxiang (17.87%) and Gardenia (17.21%) was similar, and the dose of Glycyrrhiza(10.17%) was the smallest. Conclusion 1. In the clinical application of Xiehuang San, the use of powder was changed to decoction, and the drug dosage was changed from reuse of parsnip and licorice to gypsum, supplemented with parsnip and light licorice, and often added with drugs to clear heat and nourish Yin. 2. Xiehuang San's syndrome is mainly characterized by heat syndrome and empirical evidence. The disease is caused by heat, fire or dampness, mainly relates to spleen and stomach, heart, lungs, its clinical manifestations can be summarized as: stool stem node under the hard, urinate and poor appetite, oral ulcer, oral thirst, like drinking, cough and expectoration, pharyngeal hyperemia, red tongue, yellow moss or moss yellow greasy, pulse number.