With China enters the aging society, the physical and mental health problems of middle-aged and elderly men have become prominent. Late onset hypogonadism (LOH) is a common disease in middle-aged and elderly men, which is so harmful to health.Most scholars in the field of Traditional Chinese medicine often consider and discuss the "kidney deficiency" or "kidney deficiency and liver depression" in the treatment of LOH. In this paper, the author tries to discuss the disease from "liver-Tian Gui", in order to provide a new idea for the prevention and treatment of LOH.