Oligoasthenozoospermia is one of the most common causes of male infertility. Based on the theory and clinical practice of Chinese medicine, the group proposed that this disease is caused by insufficiency of kidney essence, kidney Qi deficiency, and impassability of essence orifices as the core mechanism of the disease, which can be treated by the three methods of "opening the source, promoting the power, and clearing the passageway", and used the main formula of Yishou Yansi Ointment, which is used to benefit the kidney essence, tonify the kidney Qi and the original Qi, and warm and pass the essence orifices. The treatment with additions and subtractions according to the clinical evidence has achieved good therapeutic effects.