Male infertility refers to the situation where a couple has had normal sexual intercourse for more than one year without contraception, and the inability of the female to conceive naturally which is caused by male factors. Both domestically and internationally, a significant number of childbearing difficulties among couples of childbearing age are attributed to male factors, and male infertility has always been one of the key focuses of clinical research. Traditional Chinese medicine has unique advantage in the treatment of male infertility. Cuscuta chinensis Lam.(Cuscuta), one of the commonly used drugs for treating male infertility, exerts its effects mainly through anti-apoptosis, anti-oxidation, regulating the levels of sex hormones and hormone receptors, promoting sperm production and enhancing sperm motility, as well as supplementing trace elements and reducing body fat. This article reviews the research on the mechanism of Cuscuta in the treatment of male infertility, aiming to provide research materials and clinical references for the prevention and treatment of male infertility with traditional Chinese medicine.