Objective To explore the medication rule of contemporary famous veteran teran doctors of TCM in treating infertility based on data mining. Methods Retrieve medical cases of TCM on the treatment of infertility from CNKI, Wan fang Data, VIP and related books, then set up a database, apply the statistical and prescription analysis function of TCM inheritance support system (TCMISS) to perform disease spectrum, TCM syndrome types, frequency analysis, properties of TCM, association rules and K-means clustering analysis. Results 366 medical cases of TCM were included in the study, 421 prescriptions were obtained, 327 drugs of traditional Chinese medicine were involved, and the drugs were used for a total of 5 704 times. Ovulation disorders, tubal obstruction, decreased ovarian reserve function, endometriosis, and immune infertility are the high frequency diseases. The eight evidence types of kidney deficiency and blood stasis, spleen-kidney deficiency, stagnation of liver Qi and kidney deficiency, stagnation and blockade of phlegm-damp are identified as high-frequency evidence types. The efficacy category of Chinese medicine is most commonly used to replenish deficiency, invigorate blood circulation and remove blood stasis, with a frequency of ≥100 for 16 Chinese herbal medicines，the medicinal property was mainly warm, the medicinal taste was mainly sweet, and the meridians were mainly liver, kidney and spleen. Association rules yielded 13 core drug groups. Cluster analysis yielded 4 class parties. Conclusion Contemporary famous veteran teran doctors of TCM treat infertility by tonifying the kidney, emphasizing the theory that blood is the basis for a woman’s life, and using medicines to tonify the kidney and activate the blood, soothing liver-Qi stagnation, strengthen the spleen and promote dampness. The Chinese herbal prescriptions were based on Yulin Zhu, Yangjing Zhongyu decoction, Kaiyu Zhongyu decoction, respectively.