Objective To explore the potential mechanism of Jiawei Chushi Dingtong Recipe(JWCS) in treating gouty arthritis(GA) through network pharmacology and molecular docking technology. Methods The JWCS-related active components and targets, and GA-related targets were screened by TCMSP, DisGeNET, GeneCards and OMIM databases. Then, the "drug-component-target-disease" network and protein-protein interaction network were constructed by Cytoscape_v3.7.1 software，and DAVID was used for bioinformatics enrichment analysis. Finally，molecular docking was used to verify the binding of core targets and components. Results The core proteins of JWCS in treating GA were PTGS2, TGFβ1, IL-10, CCL2, SIRT1, Caspase-1, and so on. The effective active ingredients mainly include quercetin, 3-Epioleanolic acid, scutellarein, and so on. The main signal pathways involved included cancer, PI3K-AKT signal pathway, MAPK signal pathway, TNF signal pathway, osteoclast differentiation, Th17 cell differentiation, HIF-1 signal pathway and T cell receptor signal pathway, which were closely related to inflammatory, macrophage polarization, and efferocytosis. The results of molecular docking showed that the core target could be well combined with the main active components. Conclusion JWCS can play a role in treating GA through multi-components, multi-targets and multi-pathways, which provides basis for the clinical application of JWCS.