Objective To evaluate the effect of the comprehensive regulation acupuncture method on reducing the risk of fracture in postmenopausal women with osteoporosis. Methods The 82 observed subjects were divided into a drug control group(41 cases) and an acupuncture treatment group(41 cases) by random number table method. Both groups were given calcium supplements；the drug control group was given alendronate sodium tablets on the basis of calcium supplements；the acupuncture treatment group was given the "comprehensive regulation acupuncture method" on the basis of calcium supplements；one course of treatment was 3 months, and the efficacy was evaluated after one course of treatment:both groups were evaluated for bone density before and after treatment, FRAX fracture risk assessment, and observed the incidence of adverse reactions. Results After treatment, the BMD values, 10 years HOFP values, and MOFP values of the drug control group and acupuncture treatment group were all higher than those before treatment(P<0.05), with statistically significant differences；after treatment, the BMD values, 10 years HOFP values, and MOFP values of the drug control group and acupuncture treatment group were compared between groups, and P>0.05, with no statistically significant differences；no obvious adverse reactions occurred in both groups during the treatment process. Conclusion The comprehensive regulation acupuncture method can effectively reduce the risk of hip and major site fractures in PMOP patients within 10 years, and has good safety, which is worth clinical promotion and application. The comprehensive regulation acupuncture method may lower the MOFP and HOFP values of PMOP patients within the next ten years, which may be related to improving the bone density and lowering the BMI of patients. The relevant mechanism needs further in depth research.