Palmoplantar pustulosis is characterized by lesions in specific areas, with unclear pathogenesis and etiology, making treatment challenging. Professor Yang Enpin identifies this condition as a unique subtype of pustular psoriasis, attributing its core mechanism to "accumulation of toxic pathogens". The condition is approached by addressing dampness, heat, and blood stasis. Based on clinical manifestations, it is categorized into three patterns: excessive blood-heat with toxin exuberance, dampness-toxin downward diffusion, and blood-stasis toxin combined with wind pathogens. Treatment focuses on detoxification, heat-clearing, dampness-eliminating, and blood-stasis-resolving. Specific herbal formulas are tailored to each pattern: Jiawei Jingqin Tang, Jiawei Wushen Tang, and Huoxue Runzao Tang. Additionally, adjunct therapies such as Tripterygium hypoglaucum and insect-derived medicinal agents are incorporated based on symptom presentation, enhancing clinical efficacy.