Objective Based on data-mining analysis, this paper aims to analyze the principles of medication of Professor Zhou Jiaxuan, a renowned traditional Chinese medicine professor in Yunnan, in the treatment of chronic laryngeal obstruction of the stagnation of liver Qi and spleen deficiency type, and to summarize Zhou Jiaxuan‘s academic experience in the treatment of this type of chronic laryngeal obstruction, explore the core prescriptions of her medication to provide references and guidance for basic and clinical research, and do perform well in inheriting the academic experiences of renowned traditional Chinese medicine. Methods The cases of chronic laryngeal obstruction of the stagnation of liver Qi and spleen deficiency type diagnosed and treated by Professor Zhou Jiaxuan from January to December in 2023 were collected through outpatient medical records collection, and the frequency of using, four properties and five tastes, and meridian tropisms were statistically analyzed by the Big Data Echuancheng Platform(v3.5) (a traditional Chinese medicine Inheritance and calculation platform), so as to explore the core combination of medication and extract the core prescriptions. Results A total of 140 prescriptions were calculated, covering a total number of 134 kinds of traditional Chinese medicine, and 12 kinds of traditional Chinese medicine were used more than 100 times. The medication mainly includes drugs to reinforce deficiency, clear heat Qi, regulate Qi, resolve dampness, phlegm, cough and asthma. The properties of these herbs are mainly cold, warm and plain. Their tastes are mainly pungent, bitter and sweet. Their meridian tropisms are mainly lung meridian, spleen meridian, stomach meridian and liver meridian. 15 combinations with 2 herbs at the core, 10 combinations with 3 herbs at the core, and 1 combination with 4 drugs at the core were obtained through the analysis of the principles of prescriptions. Through the core combinations, 3 core prescriptions are concluded. Conclusion Zhou Jiaxuan‘s treatment of chronic laryngeal obstruction of the stagnation of liver Qi and spleen deficiency type is mainly cold, warm and plain, combined with the tastes of pungent, bitter and sweet, to regulate Qi and resolve dampness, phlegm and heat Qi. These prescriptions use Banxia Houpu decoction , Chaihu Shugan San and Xuanmai Ganju decoction for addition and subtraction treatment accordingly.