Objective This study aims to investigate the ameliorative effects and preliminary mechanisms of the combined herbs, Amomi Fructus and Valerianae Jatamansi Rhizoma et Radix, on gastrointestinal motility disorders (GIMD) induced by liquorice decoction in rats. Methods Sprague-Dawley(SD) rats were randomly assigned to six groups: a normal group, a model group, a positive drug group (Domperidone, DOM), and three groups receiving high, medium, and low doses of the combined herbs. GIMD in rats was induced through oral gavage of liquorice decoction. The gastric emptying rate (GER) and small intestine propelling rate(SIPR) were measured. ELISA, Western Blot, and Q-PCR were employed to assess the expression of related cytokines and proteins. Results The combined herbs alleviated the upregulation of GER and the downregulation of SIPR caused by liquorice decoction. They also elevated plasma levels of gastric power-promoting hormones, such as GAS and MTL, while reducing the content of the gastric power-inhibiting hormone, SS. Additionally, the herbs upregulated the duodenal C-kit receptor content and the expression of DHPR α2 in GIMD rats. Conclusion The combined herbs demonstrated an ameliorating effect on liquorice decoction-induced GIMD. The mechanisms of action appear to involve the elevation of gastric power-promoting hormones, a decrease in gastric power-inhibiting hormones, an increase in the number of interstitial cells of Cajal, and an upregulation of gastrointestinal smooth muscle excitability-associated DHPR.