Qi movement is the embodiment of the comprehensive physiological function of the human body. The disorder of Qi movement leads to the occurrence of diseases and the occurrence of syndromes. This paper discusses the relationship between Qi disorder and etiology of traditional Chinese medicine, and puts forward that Qi disorder is the key link among various pathological factors. Phlegm dampness, blood stasis, turbidity toxin and other pathological factors are the products of Qi disorder, as well as the causes of Qi disorder. All pathological factors interact with each other. In clinical practice, we closely follow the link of the disorder of Qi movement, and summarize the treatment ideas under the guidance of Zhang Zhen‘s academic thoughts of one body, two wings, regulating Qi movement. Specifically, the latent pathogen is excess, and the Qi movement is adjusted to reduce the excess; belong to the virtual, dredging and regulating Qi to tonic; the Qi movement is disordered, and the Qi movement is dredged to resume normal operation.