ABSTRACT: Biomechanical imbalance is considered the main reason for the formation and development of knee osteoarthritis (KOA). We study the biomechanical mechanism of knee osteoarthritis from 3 perspectives: muscle injury, ligament injury, lower extremity force line changes, and cartilage and meniscus degeneration. Tui Na massage for knee osteoarthritis has a powerful therapeutic effect. It can restore biomechanical stability of the knee joint in many ways, such as cartilage regeneration, reconstruction of subchondral structure, restoring the physiological state of muscles and ligaments, correction of the lower extremity force line, and activating mechanical receptors to regulate downstream signaling pathways. Presently, the biomechanical mechanism of Tui Na massage treatment of KOA is mostly theoretical. This article discusses the action mechanism of Tui Na massage treatment from a biomechanics perspective and emphasizes that future research should focus on standardization, quantitative evaluation, and high-quality clinical verification of Tui Na massage, which provides a theoretical basis for modern Tui Na massage application.