Objective To use data mining technology to sort out the acupuncture treatment of infertility in ancient books of traditional Chinese medicine, and provide references for clinical acupuncture treatment on infertility. Methods The relevant provisions of acupuncture and moxibustion in the treatment of infertility in the Chinese Medical Code (5th Edition) were searched, and the information of disease name, original provisions, names of acupoints, normalization of acupoints, distribution of acupoints and characteristics of acupoints were selected and extracted. The frequency, normalization of acupoints, distribution and characteristics of acupoints were statistically analyzed by using Microsoft Excel 2019，SPSS 23.0 and SPSS Modeler 18.0 were used for cluster analysis and association rule analysis, and the network diagram was drawn. Results A total of 121 acupuncture prescriptions were included, of which 94 were single-point pres-criptions and 27 were compound prescriptions. 36 acupoints were involved, and the total frequency of acupoints was 182 times. The top 4 acupoints were Guanyuan (CV4) (21 times, 11.48%), Zhongji (CV3) (17 times, 9.34%), Rangu (KI3) (12 times, 6.59%) and Yinjiao(CV7) (12 times, 6.59%). The main points were on Ren Meridian (66 times, 36.26%), Foot-Shaoyin Kidney Meridian (45 times, 24.73%) and Foot-Taiyang Bladder Meridian(19 times, 10.44%). The main parts were chest and abdomen, lower limbs and waist and back. The most frequent use of specific points was the intersection point(84 times, 46.15%), followed by the fundraising point(59 times, 32.42%). Five effective clusters were obtained by the analysis of compound association rules. The network diagram shows that the core acupoint combination of acupuncture treatment for infertility is Guanyuan (CV4)-Shimen (CV5), shiguan(KI18)-Yinjiao (CV7). Conclusion Acupuncture and moxibustion has regularity in treating infertility. Guanyuan, Zhongji, Rangu and Yinjiao are used most frequently. Guanyuan (CV4), Shimen (CV5), Shiguan (KI18) and Yinjiao (CV7) are the compatible core points, emphasizing the matching of points near and far and selecting points according to the disease.