Influenza is highly contagious and spreads quickly, which can easily cause outbreaks and epidemics. Toxic evil is a type of pathogenic factor that causes disease rapidly. The source of toxicity is mostly heat, which often turns into toxicity, and toxicity often contains heat. Heat and toxicity often coexist in a stagnant state. This article analyzes the connotation and pathogenic characteristics of heat toxicity, and combines the characteristics of influenza to explain the significance of "heat toxicity" in the onset and treatment of influenza. The important pathogenesis of influenza is the intersection of heat and toxicity, which stagnates in the lungs. The treatment of heat toxicity is the key to the treatment of this disease. In the treatment of influenza, attention should be paid to the transmission and transformation of heat toxicity in "Wei Qi Ying Xue", and the pathogenesis should be strictly adhered to. In treatment, attention should be paid to clearing heat and detoxification, preventing toxicity from turning into heat, leading toxicity out, and focusing on strengthening the body, eliminating evil, and replenishing Qi and nourishing Yin. This article summarizes and discusses the etiology, pathogenesis and treatment strategies of influenza by explaining the connotation and pathogenic characteristics of "heat toxicity", and provides new ideas for the treatment of influenza from the perspective of heat toxicity.