Although neuroendocrine neoplasms(NENs) are comparatively rare neoplasms, the incidence rate has been on the rise in recent years, with gastroenteropancreatic neuroendocrine neoplasms(GEP-NENs) being the most common subtype. Traditional Chinese medicine(TCM) is a treasure of Chinese culture, with a clinical practice history spanning thousands of years, reflecting the unique originality and strategic advantage of the Chinese nation. TCM has its unique curative effect in the treatment of major and difficult diseases, and has made positive contributions to the treatment of tumors and other major diseases. TCM, combined with western medicine, can synergistically enhance efficiency. At present, the research on TCM prevention and treatment of GEP-NENs in China is still in its infancy with relatively limited studies available. This paper reviews the research progress of prevention and treatment of GEP-NENs with TCM in recent years. This paper systematically collects the theoretical, experimental and clinical researches on the prevention and treatment of GEP-NENs using TCM from the perspectives of theory, therapy, prescription and medicine, in order to summarize the previous researches. Most medical professionals believe that the pathogenesis of GEP-NENs is spleen deficiency, Qi stagnation, phlegm and blood stasis. GEP-NENs is treated with tonifying Qi and strengthening the spleen, regulating Qi and relieving depression, resolving phlegm and removing blood stasis. The prescription is mostly based on Liujunzi Decoction, with modifications and adjustments made according to the specific symptoms of the patient. The etiology, pathogenesis TCM therapy, prescription and medicine of GEP-NENs are generalized, so as to supply some theoretical basis for syndrome differentiation and treatment, for providing and inspiration for further related researches in the future.